A new family of cystine knot peptides from the seeds of Momordica cochinchinensis

Chan, Lai Yue, He, Wenjun, Tan, Ninghua, Zeng, Guangzhi, Craik, David J., and Daly, Norelle L. (2013) A new family of cystine knot peptides from the seeds of Momordica cochinchinensis. Peptides, 39. pp. 29-35.

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Abstract

Momordica cochinchinensis, a Cucurbitaceae plant commonly found in Southeast Asia, has the unusual property of containing both acyclic and backbone-cyclized trypsin inhibitors with inhibitor cystine knot (ICK) motifs. In the current study we have shown that M. cochinchinensis also contains another family of acyclic ICK peptides. We recently reported two novel peptides from M. cochinchinensis but have now discovered four additional peptides (MCo-3–MCo-6) with related sequences. Together these peptides form a novel family of M. cochinchinensis ICK peptides (MCo-ICK) that do not have sequence homology with other known peptides and are not potent trypsin inhibitors. Otherwise these new peptides MCo-3 to MCo-6 were evaluated for antimalarial activity against Plasmodium falciparum, and cytotoxic activity against the cancer cell line MDA-MB-231. But these peptides were not active.

Item ID: 25820
Item Type: Article (Research - C1)
ISSN: 1873-5169
Funders: National Natural Science Foundation of China (U1032602, 91013002, 21202174, 30725048), China/Australia Special Fund for S & T (NSFC and ARC), National New Drug Innovation Great Project of China (2011ZX09307-002-02), National Basic Research Program of China (2009CB522300 and 2012CB017104), Foundation of Chinese Academy of Sciences (Hundred Talents Program and KSCXZ-EW-R-15)
Date Deposited: 22 Mar 2013 05:35
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1101 Medical Biochemistry and Metabolomics > 110106 Medical Biochemistry: Proteins and Peptides (incl Medical Proteomics) @ 100%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 100%
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