Total (bio)synthesis: strategies of nature and of chemists

Roberts, Alexandra A., Ryan, Katherine S., Moore, Bradley S., and Gulder, Tobias A.M. (2010) Total (bio)synthesis: strategies of nature and of chemists. Topics in Current Chemistry, 297. pp. 149-203.

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Abstract

The biosynthetic pathways to a number of natural products have been reconstituted in vitro using purified enzymes. Many of these molecules have also been synthesized by organic chemists. Here we compare the strategies used by nature and by chemists to reveal the underlying logic and success of each total synthetic approach for some exemplary molecules with diverse biosynthetic origins.

Item ID: 25727
Item Type: Article (Research - C1)
ISSN: 1436-5049
Keywords: biocatalysis, biosynthesis, in vitro reconstitution, natural products, total synthesis
Date Deposited: 04 Sep 2013 05:40
FoR Codes: 03 CHEMICAL SCIENCES > 0305 Organic Chemistry > 030503 Organic Chemical Synthesis @ 30%
06 BIOLOGICAL SCIENCES > 0601 Biochemistry and Cell Biology > 060107 Enzymes @ 30%
03 CHEMICAL SCIENCES > 0304 Medicinal and Biomolecular Chemistry > 030401 Biologically Active Molecules @ 40%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970103 Expanding Knowledge in the Chemical Sciences @ 50%
97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 50%
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