Ovenden, Simon P.B., Nielson, Jonathan L., Liptrot, Catherine H., Willis, Richard H., Tapiolas, Dianne M., Wright, Anthony D., and Motti, Cherie A. (2011) Sesquiterpene benzoxazoles and sesquiterpene quinones from the marine sponge Dactylospongia elegans. Journal of Natural Products, 74 (1). pp. 65-68.

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Abstract

A new sesquiterpene benzoxazole, nakijinol B (3), its acetylated derivative, nakijinol B diacetate (6), and two new sesquiterpene quinones, smenospongines B (4) and C (5), were isolated from the methanol extract of the marine sponge Dactylospongia elegans. Also isolated were the known compounds dactyloquinone B and a 1:1 mixture of ilimaquinone and 5-epi-ilimaquinone. Their structures were determined on the basis of spectroscopic analyses and comparison with literature data. The isolated compounds were assessed for their cytotoxicity against a panel of human tumor cell lines (SF-268, H460, MCF-7, and HT-29) and a normal mammalian cell line (CHO-K1). All compounds were found to have activities in the range 1.8−46 μM and lacked selectivity for tumor versus normal cell lines.

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