Metachromins U-W: Cytotoxic merosesquiterpenoids from an Australian specimen of the sponge Thorecta reticulata

Ovenden, S.P.B., Nielson, Jonathan L., Liptrot, Catherine H., Willis, Richard H., Tapiolas, Dianne M., Wright, Anthony D., and Motti, Cherie A. (2011) Metachromins U-W: Cytotoxic merosesquiterpenoids from an Australian specimen of the sponge Thorecta reticulata. Journal of Natural Products, 74 (5). pp. 1335-1338.

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DOI: 10.1021/np200041v

View at Publisher Website: http://dx.doi.org/10.1021/np200041v

Abstract

Three new merosesquiterpenoids, metachromins U, V, and W (1–3), were isolated from a specimen of the marine sponge Thorecta reticulata collected off Hunter Island, Tasmania, Australia. Structures of the new compounds were elucidated through extensive NMR investigations and comparison with literature values. The cytotoxicities of 1–3 were assessed against a panel of human tumor cell lines (SF-268, H460, MCF-7, and HT-29) and a mammalian cell line (CHO-K1). All compounds were found to have 50% growth inhibition activities in the range 2.1–130 μM, with 2 being the most active (GI50 2.1–10 μM).


Item ID:	21802
Item Type:	Article (Research - C1)
ISSN:	1520-6025
Date Deposited:	08 May 2012 06:35
FoR Codes:	03 CHEMICAL SCIENCES > 0304 Medicinal and Biomolecular Chemistry > 030401 Biologically Active Molecules @ 25% 03 CHEMICAL SCIENCES > 0304 Medicinal and Biomolecular Chemistry > 030403 Characterisation of Biological Macromolecules @ 25% 10 TECHNOLOGY > 1002 Environmental Biotechnology > 100201 Biodiscovery @ 50%
SEO Codes:	97 EXPANDING KNOWLEDGE > 970103 Expanding Knowledge in the Chemical Sciences @ 50% 97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 50%
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