A new Diketopiperazine, cyclo-(4-S-hydroxy-R-proline-R-isoleucine), from an Australian specimen of the sponge Stelletta sp

Ovenden, Simon P.B., Nielson, Jonathan L., Liptrot, Catherine H., Willis, Richard H., Tapiolas, Dianne M., Wright, Anthony D., and Motti, Cherie A. (2011) A new Diketopiperazine, cyclo-(4-S-hydroxy-R-proline-R-isoleucine), from an Australian specimen of the sponge Stelletta sp. Marine Drugs, 9 (11). pp. 2469-2478.

[img] PDF (Published Version) - Published Version
Available under License Creative Commons Attribution.

Download (311kB)
View at Publisher Website: http://dx.doi.org/10.3390/md9112469
 
17
1102


Abstract

While investigating the cytotoxic activity of the methanol extract of an Australian marine sponge Stelletta sp. (Demospongiae), a new diketopiperazine, cyclo-(4-S-hydroxy-R-proline-R-isoleucine) (1), was isolated together with the known bengamides; A (2), F (3), N (4), Y (5), and bengazoles; Z (6), C4 (7) and C6 (8). The isolation and structure elucidation of the diketopiperazine (1), together with the activity of 1–8 against a panel of human and mammalian cell lines are discussed.

Item ID: 21801
Item Type: Article (Research - C1)
ISSN: 1660-3397
Keywords: Stelletta; diketopiperazine (DKP); cyclo-(4-S-hydroxy-R-proline-R-isoleucine); bengamide; bengazole; anti-cancer activity
Additional Information:

Creative Commons Attribution License

Date Deposited: 08 May 2012 06:12
FoR Codes: 03 CHEMICAL SCIENCES > 0304 Medicinal and Biomolecular Chemistry > 030401 Biologically Active Molecules @ 25%
03 CHEMICAL SCIENCES > 0304 Medicinal and Biomolecular Chemistry > 030403 Characterisation of Biological Macromolecules @ 25%
10 TECHNOLOGY > 1002 Environmental Biotechnology > 100201 Biodiscovery @ 50%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970103 Expanding Knowledge in the Chemical Sciences @ 75%
97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 25%
Downloads: Total: 1102
Last 12 Months: 6
More Statistics

Actions (Repository Staff Only)

Item Control Page Item Control Page