Behavioral and molecular biomarkers in translational animal models for neuropsychiatric disorders

Sarnyai, Zoltán, Alsaif, Murtada, Bahn, Sabine, Ernst, Agnes, Guest, Paul C., Hradetzky, Eva , Kluge, Wolfgang, Stelzhammer, Viktoria , and Wesseling, Hendrik (2011) Behavioral and molecular biomarkers in translational animal models for neuropsychiatric disorders. In: Bah, Sabine, and Guest, Paul C., (eds.) Biomarkers of Neurological and Psychiatric Disease. International Review of Neurobiology , 101 . Elsevier, London, UK, pp. 203-238.

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Modeling neuropsychiatric disorders in animals poses a significant challenge due to the subjective nature of diverse often overlapping symptoms, lack of objective biomarkers and diagnostics, and the rudimentary understanding of the pathophysiology. Successful translational research requires animal models that can inform about disease mechanisms and therapeutic targets. Here, we review behavioral and neurobiological findings from selected animal models, based on presumed etiology and risk factors, for schizophrenia, bipolar disorder, and major depressive disorder. We focus on the use of appropriate statistical tools and newly developed Research Domain Criteria (RDoC) to link biomarkers from animal models with the human disease. We argue that this approach will lead to development of only the most robust animal models for specific psychiatric disorders and may ultimately lead to better understanding of the pathophysiology and identification of novel biomarkers and therapeutic targets.

Item ID: 20747
Item Type: Book Chapter (Research - B1)
ISBN: 978-0-12-387718-5
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Date Deposited: 17 Apr 2012 05:20
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1109 Neurosciences > 110999 Neurosciences not elsewhere classified @ 100%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 100%
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