Influence of transgenic corticotropin-releasing factor (CRF) over-expression on social recognition memory in mice

Kasahara, Maki, Groenink, Lucianne, Kas, Martien J.H., Bijlsma, Elisabeth Y., Olivier, Berend, and Sarnyai, Zoltán (2011) Influence of transgenic corticotropin-releasing factor (CRF) over-expression on social recognition memory in mice. Behavioural Brain Research, 218 (2). pp. 357-362.

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Abstract

We examined juvenile social recognition and discrimination in mice with early post-natal onset, transgenic CRF over-expression (CRF-OE) and in their wild-type littermates (WT). CRF-OE mice showed enhanced social investigation during the first encounter, normal short-term and facilitated long-term social recognition memory, compared to WT. These results suggest that chronically elevated brain CRF tone may contribute in better remembering ethologically relevant and emotionally salient stimuli, such as social interaction.

Item ID: 20726
Item Type: Article (Refereed Research - C1)
ISSN: 0166-4328
Date Deposited: 19 Apr 2012 06:32
FoR Codes: 06 BIOLOGICAL SCIENCES > 0601 Biochemistry and Cell Biology > 060105 Cell Neurochemistry @ 100%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 100%
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