Sarnyai, Zoltán, and Boros, László G. (2008) Modeling networks of glycolysis, overall energy metabolism and drug Metabolism under a systems biology approach. Annual Reports in Medicinal Chemistry, 43. pp. 329-349.

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Abstract

This chapter presents systems biology as a tool to understand perturbations in mammalian metabolism caused by disease and medicine. Like the empirical and sometimes serendipitous methods of drug discovery and evaluation that came before it, the molecular-target approach of modeling metabolism of energy and drugs is increasingly recognized as only a partial—and often too simple—answer to biological questions that are more complex than was fully appreciated until relatively recently. The realization that all biochemical phenomena within an organism have important and varying influence on each other depending of many variables is too late to be applied to metabolic modeling and drug discovery and development. A systems biology approach incorporates both the micro- and macro-views of organism function in health and disease. Improved models of such function are most likely to help break the logjam of stalled progress in developing more effective treatments in a wide variety of diseases. Evolving are more accurate models in vivo, ex vivo and in silico, and combinations as interactive and dynamic in change as the biologic systems they represent.

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