Watson, Gregory S., Watson, Jolanta A., and Myhra, Sverre (2007) Morphology, mechanical properties and manipulation of living cells: atomic force microscopy. In: Ivanova, Elena P., (ed.) Nanoscale Structure and Properties of Microbial Cell Surfaces. Nova Science Publishers, New York, NY, USA, pp. 145-173.

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Abstract

Atomic force microscopy (AFM) is becoming an increasingly important tool-of-the-trade in the life sciences. In the study of morphology and dynamics of cells it has the particular merit of being able to interact non-destructively with live cells in vitro. Thus it occupies a unique niche in the suite of techniques that has so far been dominated by the photon- and electron-optical microscopies and spectroscopies. In addition, AFM in the lateral force and force-versus-distance operational modes can gain access to information that cannot be obtained by other means. Recent results obtained by AFM analysis of human fibroblasts and cancer cells (MDA) are described and discussed.

Item ID:	18548
Item Type:	Book Chapter (Research - B1)
ISBN:	978-1-60021-242-0
Keywords:	Atomic Force Microscopy, fibroblasts, cancer cells, mechanical properties, F-d curves, morphology
Date Deposited:	31 Oct 2011 06:41
FoR Codes:	02 PHYSICAL SCIENCES > 0299 Other Physical Sciences > 029901 Biological Physics @ 40% 06 BIOLOGICAL SCIENCES > 0601 Biochemistry and Cell Biology > 060106 Cellular Interactions (incl Adhesion, Matrix, Cell Wall) @ 40% 06 BIOLOGICAL SCIENCES > 0601 Biochemistry and Cell Biology > 060199 Biochemistry and Cell Biology not elsewhere classified @ 20%
SEO Codes:	97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 80% 97 EXPANDING KNOWLEDGE > 970102 Expanding Knowledge in the Physical Sciences @ 20%
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