Analysis of evolutionarily conserved innate immune components in coral links immunity and symbiosis

Kvennefors, E. Charlotte E., Leggat, William, Kerr, Caroline C., Ainsworth, Tracy D., Hoegh-Guldberg, Ove, and Barnes, Andrew C. (2010) Analysis of evolutionarily conserved innate immune components in coral links immunity and symbiosis. Developmental and Comparative Immunology, 34 (11). pp. 1219-1229.

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Abstract

Reef-building corals are representatives of one of the earliest diverging metazoan lineages and are experiencing increases in bleaching events (breakdown of the coral-Symbiodinium symbiosis) and disease outbreaks. The present study investigates the roles of two pattern recognition proteins, the mannose binding lectin Millectin and a complement factor C3-like protein (C3-Am), in the coral Acropora millepora. The results indicate that the innate immune functions of these molecules are conserved and arose early in evolution. C3-Am is expressed in response to injury, and may function as an opsonin. In contrast, Millectin expression is up-regulated in response to lipopolysaccharide and peptidoglycan. These observations, coupled with localization of Millectin in nematocysts in epidermal tissue, and reported binding of pathogens, are consistent with a key role for the lectin in innate immunity. Furthermore, Millectin was consistently detected binding to the symbiont Symbiodinium in vivo, indicating that the Millectin function of recognition and binding of non-self-entities may have been co-opted from an ancient innate immune system into a role in symbiosis.

Item ID: 14931
Item Type: Article (Refereed Research - C1)
Keywords: coral; immunity; symbiosis; complement C3; mannose binding lectin; Acropora millepora
ISSN: 1879-0089
Date Deposited: 12 Nov 2010 06:54
FoR Codes: 06 BIOLOGICAL SCIENCES > 0601 Biochemistry and Cell Biology > 060114 Systems Biology @ 100%
SEO Codes: 96 ENVIRONMENT > 9603 Climate and Climate Change > 960307 Effects of Climate Change and Variability on Australia (excl. Social Impacts) @ 100%
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