High Prevalence of RET proto-oncogene activation (RET/PTC) in papillary thyroid carcinomas

Lam, King Yin, Lo, Chung Yau, and Leung, Po Sing (2002) High Prevalence of RET proto-oncogene activation (RET/PTC) in papillary thyroid carcinomas. European Journal of Endocrinology, 147 (6). pp. 741-745.

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OBJECTIVE: The activation of RET proto-oncogene, through different types of chromosomal translocation and inversion, is unique to papillary thyroid carcinomas (PTC) and its frequency is variable in different populations. The aim of this study was to investigate the frequency and types of PTC genetic rearrangements in papillary carcinoma in a population of Hong Kong Chinese.

METHODS: The presence of RET/PTC1, RET/PTC2 and RET/PTC3 activation was analyzed by RT-PCR in twenty PTC from adult patients (age range 24-63 years), one PTC from a 12-year-old boy and anaplastic carcinomas in two adult patients.

RESULTS: RET/PTC3 was the only activation of RET proto-oncogene identified in the samples. Seventeen PTC from adult patients (85%t) were positive for RET/PTC3. RET/PTC3 was also identified in PTC from the child and one of the two patients with anaplastic thyroid carcinoma.

CONCLUSIONS: The prevalence of RET/PTC activation in PTC is high and RET/PTC3 is the only type of activation identified in Hong Kong Chinese and is an important genetic event underlying the development of PTC in the population.

Item ID: 13517
Item Type: Article (Research - C1)
ISSN: 1479-683X
Keywords: cancer; carcinogenesis; thyroid functions
Date Deposited: 22 Dec 2010 04:53
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111708 Health and Community Services @ 100%
SEO Codes: 93 EDUCATION AND TRAINING > 9399 Other Education and Training > 939999 Education and Training not elsewhere classified @ 100%
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