Selective mitochondrial accumulation of cytotoxic dinuclear polypyridyl ruthenium(II) complexes

Pisani, Michelle J., Weber, Daniel K., Heimann, Kirsten, Collins, J. Grant, and Keene, F. Richard (2010) Selective mitochondrial accumulation of cytotoxic dinuclear polypyridyl ruthenium(II) complexes. Metallomics, 2 (6). pp. 393-396.

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Abstract

The lipophilic ligand-bridged dinuclear cation Rubb16 is significantly cytotoxic and preferentially accumulates in the mitochondria of the L1210 murine leukemia cancer cell line.

Item ID: 11649
Item Type: Article (Refereed Research - C1)
Keywords: mitochondria; ruthenium; dinuclear; cytotoxicity; cancer
ISSN: 1756-591X
Funders: Australian Research Council
Date Deposited: 05 Aug 2010 05:36
FoR Codes: 03 CHEMICAL SCIENCES > 0302 Inorganic Chemistry > 030201 Bioinorganic Chemistry @ 50%
03 CHEMICAL SCIENCES > 0302 Inorganic Chemistry > 030207 Transition Metal Chemistry @ 50%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970103 Expanding Knowledge in the Chemical Sciences @ 80%
97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 20%
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