Sharma, Mridula, McFarlane, Craig, Kambador, Ravi, Kukreti, Himani, Bonala, Sabeera, and Srinivasan, Shruti (2015) Myostatin: expanding horizons. IUBMB Life, 67 (8). pp. 589-600.

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Abstract

Myostatin is a secreted growth and differentiation factor that belongs to the TGF-b superfamily. Myostatin is predominantly synthesized and expressed in skeletal muscle and thus exerts a huge impact on muscle growth and function. In keeping with its negative role in myogenesis, myostatin expression is tightly regulated at several levels including epigenetic, transcriptional, post-transcriptional, and post-translational. New revelations regarding myostatin regulation also offer mechanisms that could be exploited for developing myostatin antagonists. Increasingly, it is becoming clearer that besides its conventional role in muscle, myostatin plays a critical role in metabolism. Hence, molecular mechanisms by which myostatin regulates several key metabolic processes need to be further explored.

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