ESI FTICR-MS analysis of larvae from the marine sponge Luffariella variabilis
Motti, Cherie A., Ettinger-Epstein, Piers, Willis, Richard H., and Tapiolas, Dianne M. (2010) ESI FTICR-MS analysis of larvae from the marine sponge Luffariella variabilis. Marine Drugs, 8 (1). pp. 190-199.
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The viviparous Great Barrier Reef sponge Luffariella variabilis (Poléjaeff 1884) contains a range of secondary metabolites, including manoalide (1) and manoalide monoacetate (3). ESI (+) FTICR-MS accurate mass determination has, for the first time, been used to detected the presence of 3 only in an organic extract of a single L. variabilis larva showing that the parentally produced 3 is sequestered in the larva. As 3 has previously been shown to have antibacterial and quorum sensing inhibition activity, and readily converts to 1, which also exhibits similar activity, it may provide a chemical defence against predation and microbial attack.
|Item Type:||Article (Refereed Research - C1)|
|Keywords:||Luffariella variabilis; manoalide monoacetate; larvae; ESI FTICR-MS; constitutive defence|
|Date Deposited:||16 May 2011 01:01|
|FoR Codes:||06 BIOLOGICAL SCIENCES > 0601 Biochemistry and Cell Biology > 060101 Analytical Biochemistry @ 100%|
|SEO Codes:||97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 100%|
|Citation Count from Web of Science||