Infection with the trypanosome Crithidia bombi and expression of immune-related genes in the bumblebee Bombus terrestris

Schlüns, Helge, Sadd, Ben M., Schmid-Hempel, Paul, and Crozier, Ross H. (2010) Infection with the trypanosome Crithidia bombi and expression of immune-related genes in the bumblebee Bombus terrestris. Developmental and Comparative Immunology, 34 (7). pp. 705-709.

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Abstract

Social bees and other insects are frequently parasitized by a large range of different microorganisms. Among these is Crithidia bombi (Kinetoplastida: Trypanosomatidae), a common gut parasite of bumblebees, Bombus spp. (Insecta: Apidae). Bumblebees are important pollinators in commercial and natural environments. There are clear detrimental effects of C. bombi infections on the fitness of bumblebees. However, little has been known about how the bee's immune system responds to infections with trypanosome parasites. Here, we study the immune response of Bombus terrestris on infection byC. bombi. We measured the expression of four immune-related genes (Hemomucin, MyD88, Relish, and TEP7) using RT-qPCR in adult B. terrestris workers that were either healthy or infected with the trypanosome parasite C. bombi. The potential recognition gene Hemomucin was significantly upregulated in the infected bees. Further, there was substantial and significant variation in all four genes among different bumblebee colonies irrespective of infection status.

Item ID: 10617
Item Type: Article (Refereed Research - C1)
Keywords: tropical biology, conservation, Hemomucin, MyD88, Relish, TEP7, real-time PCR, Apidae, Trypanosomatidae
ISSN: 1879-0089
Date Deposited: 06 Aug 2010 01:35
FoR Codes: 06 BIOLOGICAL SCIENCES > 0608 Zoology > 060808 Invertebrate Biology @ 50%
06 BIOLOGICAL SCIENCES > 0608 Zoology > 060804 Animal Immunology @ 50%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 100%
Citation Count from Web of Science Web of Science 12
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