Publications by: Sacha A. Jensen
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Jensen, Sacha A., Atwa, Ondine, and Handford, Penny A. (2021) Assembly assay identifies a critical region of human fibrillin-1 required for 10 - 12 nm diameter microfibril biogenesis. PLoS ONE, 16 (3). e0248532.
Pfeffer, Inga, Brewitz, Lennart, Krojer, Tobias, Jensen, Sacha A., Kochan, Grazyna T., Kershaw, Nadia J., Hewitson, Kirsty S., McNeill, Luke A., Kramer, Holger, Münzel, Martin, Hopkinson, Richard J., Oppermann, Udo, Handford, Penny A., McDonough, Michael A., and Schofield, Christopher J. (2019) Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern. Nature Communications, 10. 4910.
Del Cid, Joselyn S., Isik Reed, Nilgun, Molnar, Kathleen, Liu, Sean, Dang, Bobo, Jensen, Sacha A., DeGrado, William, Handford, Penny, Sheppard, Dean, and Sundaram, Aparna B. (2019) A disease associated mutation in fibrillin-1 differentially regulates integrin mediated cell adhesion. Journal of Biological Chemistry, 294 (48). pp. 18232-18243.
Robertson, Ian B., Dias, Hans F., Osuch, Isabelle H., Lowe, Edward D., Jensen, Sacha A., Redfield, Christina, and Handford, Penny A. (2017) The N-terminal region of Fibrillin-1 mediates a bipartite interaction with LTBP1. Structure, 25 (8). 1208-1221.e5.
Jensen, Sacha A., and Handford, Penny A. (2016) New insights into the structure, assembly and biological roles of 10–12 nm connective tissue microfibrils from fibrillin-1 studies. Biochemical Journal, 473 (7). pp. 827-838.
Jensen, Sacha A., Iqbal, Sarah, Bulsiewicz, Alicja, and Handford, Penny A. (2015) A microfibril assembly assay identifies different mechanisms of dominance underlying Marfan syndrome, stiff skin syndrome and acromelic dysplasias. Human Molecular Genetics, 24 (15). pp. 4454-4463.
Jensen, Sacha A., Aspinall, Georgia, Handford, Penny A., and UNSPECIFIED (2014) C-terminal propeptide is required for fibrillin-1 secretion and blocks premature assembly through linkage to domains cbEGF41-43. Proceedings of the National Academy of Sciences of the United States of America, 111 (28). pp. 10155-10160.