Schaeffel, Frank, and Megaw, Pam (2009) Symposium 10: signalling cascades in Myopia development: where does it start and where does it end? In: Papers from the 12th International Myopia Conference (86) p. 63. From: 12th International Myopia Conference, 8–11 July 2008.

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Abstract

This symposium gave an overview on the current status of the research on the signalling cascades which link retinal image processing to scleral growth. Messengers are released from the retina, reach the retinal pigment epithelium, RPE (most likely by diffusion), stimulate its receptors to release secondary messengers from the RPE that are finally transmitted through the choroid. Regan Ashby, Postdoctoral fellow in the RTN “MyEuropia” (Tuebingen, Germany) reported on the modulation of the immediate early gene Egr1 by imposed defocus, and on work underway to identify its potential target genes. Marita Feldkaemper, same place, described the roles of the glucagon/insuline system, with the striking finding that insulin is a most potent stimulator of myopia in the chicken model. Katrina Schmidt (Brisbane) reported on the roles of dopaminergic and cholinergic transmission, as well as GABA, and how these two transmitter systems interact. Deborah Nickla (NewEnco, Boston) focused on the interaction of nitric oxide signalling with muscarinic and dopaminergic transmission, and how they affect choroidal thickening - an effect that is tightly related to eye growth inhibition. Finally, Andrew Jobling (University of Melbourne) described the end of the signalling cascade in the sclera, involving TGF-beta, matrix metalloproteinases and cell-specific matrix cell receptors, the integrins, to remodel its structure and growth.

Item ID:	9843
Item Type:	Conference Item (Abstract / Summary)
ISSN:	1040-5488
Date Deposited:	14 May 2010 02:04
FoR Codes:	06 BIOLOGICAL SCIENCES > 0606 Physiology > 060603 Animal Physiology Systems @ 70% 06 BIOLOGICAL SCIENCES > 0606 Physiology > 060602 Animal Physiology - Cell @ 30%
SEO Codes:	92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920107 Hearing, Vision, Speech and Their Disorders @ 100%
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