Detection of papillomaviral DNA sequences in a feline oral squamous cell carcinoma

Munday, J.S., Howe, L., French, A., Squires, R.A., and Sugiarto, H. (2009) Detection of papillomaviral DNA sequences in a feline oral squamous cell carcinoma. Research in Veterinary Science, 86 (2). pp. 359-361.

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Oral squamous cell carcinomas (OSCCs) are common and often fatal feline neoplasms. Factors that predispose to neoplasm development in cats are poorly defined. Around 25% of human OSCCs are caused by papillomaviruses (PVs). To determine if PVs are associated with OSCCs in cats, three sets of consensus primers were used to evaluate 20 feline OSCCs and 20 non-neoplastic feline oral lesions for the presence of PV DNA. Papillomaviral sequences were detected within one OSCC, but no non-neoplastic lesion. Sequencing of the amplified DNA revealed a previously unreported PV that was most similar to human PV type 76. This is the first time PV DNA has been amplified from the oral cavity of a cat. However, while these results suggest that feline gingival epithelial cells can be infected by PVs, they do not support a causal association between viral infection and the development of feline OSCCs.

Item ID: 9741
Item Type: Article (Research - C1)
ISSN: 1532-2661
Keywords: papillomavirus; cat; neoplasia; squamous cell carcinoma
Date Deposited: 19 Apr 2010 02:57
FoR Codes: 07 AGRICULTURAL AND VETERINARY SCIENCES > 0707 Veterinary Sciences > 070706 Veterinary Medicine @ 100%
SEO Codes: 86 MANUFACTURING > 8609 Veterinary Pharmaceutical Products > 860902 Veterinary Diagnostics @ 100%
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