Cornet, Arthur, Schwob, Jean-Marc, Roussel, Camille, Cordaillat, Romain, Nsanzabana, Christian, Kuenzli, Esther, Zimmermann, Rosalie, Neumayr, Andreas, Buffet, Pierre, Eperon, Gilles, and Musumeci, Stefano (2026) Persistent non-viable Plasmodium falciparum parasitemia mimicking artesunate treatment failure and unmasking functional hyposplenism. International Journal of Infectious Diseases, 171. 109036.

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Abstract

A 40-year-old woman was admitted with severe Plasmodium falciparum malaria. Although she improved clinically under intravenous artesunate, parasitemia unexpectedly increased. Reassessment identified previously unrecognized functional hyposplenism, leading to delayed clearance of non-viable parasites and falsely suggesting artemisinin resistance.

Item ID:	94533
Item Type:	Article (Case Study)
ISSN:	1878-3511
Copyright Information:	© 2026 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Date Deposited:	02 Nov 2026 03:55
FoR Codes:	32 BIOMEDICAL AND CLINICAL SCIENCES > 3207 Medical microbiology > 320704 Medical parasitology @ 100%
SEO Codes:	20 HEALTH > 2001 Clinical health > 200101 Diagnosis of human diseases and conditions @ 100%
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