Mohammed, Mahmud, Jesmin, Fabiha, Kassim, Nur Karyatee, Zainuddin, Siti Lailatul Akmar, Hanafi, Muhammad Hafiz, Kamarudin, Muhammad Imran, Ahmad, Farizan, and Sirajudeen, K.N.S. (2021) Levels of interleukins in patients with chronic kidney disease and periodontitis: A systematic review. Journal of International Oral Health, 13. pp. 313-317.

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Abstract

Aim: To systematically review the in vivo clinical studies available in the literature evaluating the effect of interleukin (IL) in patients with chronic kidney disease (CKD) and chronic periodontitis (CP).

Materials and Methods: A search was initially performed using Scopus, PubMed, and Web of Science databases published from the year 2003 to 2020. Among the keywords used in the search were “periodontal diseases,” “interleukin,” “chronic kidney diseases,” and “inflammation.” After relevant articles were found, a critical assessment was made to select those that met the criteria for the systematic review. Among the inclusion criteria needed for the papers were randomized clinical trials, longitudinal clinical trials, clinical studies, no sample size limits, and only English language articles. Case reports, conference abstracts, and unpublished data were excluded for this study.

Result: Based on the keywords, 16 of the relevant articles were listed and seven of them were selected for a systematic review.

Conclusion: After reviewing the articles based on their results and conclusion, it can be concluded that serum IL level increased significantly in patients with CKD and CP and periodontal therapy can significantly reduce the level of serum IL. Moreover, the effect of modern periodontal therapy in CKD and CP is still unknown and inflammatory gene expression profile in patients with CKD will still need to be evaluated within different populations.

Item ID:	93872
Item Type:	Article (Research - C1)
ISSN:	0976-1799
Copyright Information:	© 2021 Journal of International Oral Health. This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
Date Deposited:	01 Sep 2026 01:54
FoR Codes:	32 BIOMEDICAL AND CLINICAL SCIENCES > 3203 Dentistry > 320310 Periodontics @ 100%
SEO Codes:	20 HEALTH > 2001 Clinical health > 200101 Diagnosis of human diseases and conditions @ 100%
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