Moazzami, Bobak, Mohammadpour, Zinat, Zabala, Zohyra, and Chawla, Saurabh (2024) The Effect of Epidural Analgesia on In-Hospital Outcomes in Patients With Acute Pancreatitis: A Systematic Review and Meta-Analysis. In: American Journal of Gastroenterology (119) S53. S40-S40. From: ACG 2024: American College of Gastroenterology 2024 Annual Scientific Meeting, 25-30 October 2024, Philadelphia, PA, USA.

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Abstract

Introduction: Necrotizing pancreatitis (NP) is a severe and life-threatening form of acute pancreatitis and is frequently associated with organ dysfunction, necessitating intensive care management. The presence of Clostridioides difficile infection (CDI), a common nosocomial infection, can further complicate the clinical course of NP by exacerbating gastrointestinal symptoms and increasing the risk of sepsis. This study aims to analyze the prevalence and outcomes in NP patients with a concurrent CDI.

Methods: Using the National Readmission Database 2016-2020, we employed the International Classification of Diseases, 10th revision, Clinical Modifications (ICD-10-CM) codes to identify adult patients (age .18 years) admitted with NP. We further stratified NP hospitalizations based on the presence of CDI. Utilizing a multivariate regression model, we compared the outcomes of NP in patients with CDI. STATA 14.2 was utilized for statistical analysis.

Results: We included 68,839 NP patients, of whom 1,217 (1.77%) had CDI. Adjusted analysis showed significantly higher odds of mortality (adjusted odds ratio [aOR]:2.99, P, 0.001), septic shock (aOR:4.94, P, 0.01), acute kidney injury requiring dialysis (AKId) (aOR:2.31, P, 0.001) and ICU admission (aOR:3.53, P, 0.001) in NP patients with CDI (Table 1). Pancreatitis-specific complications such as pancreatic pseudocyst, portal vein thrombosis, and infection of necrosis requiring necrosectomy were also higher in patients with a CDI. Moreover, NP patients with CDI also had higher odds of developing abdominal compartment syndrome, a rare life-threatening complication.

Conclusion: The presence of CDI in patients with NP is associated with higher rates of pancreatitis-specific complications and significantly worse hospitalization outcomes. These findings underscore the importance of vigilant monitoring and proactive management of CDI in NP patients to improve outcomes and reduce the healthcare burden.

Item ID:	93856
Item Type:	Conference Item (Abstract / Summary)
ISSN:	1572-0241
Copyright Information:	Copyright © 2024 by The American College of Gastroenterology
Date Deposited:	31 Aug 2026 05:07
FoR Codes:	42 HEALTH SCIENCES > 4299 Other health sciences > 429999 Other health sciences not elsewhere classified @ 100%
SEO Codes:	20 HEALTH > 2001 Clinical health > 200199 Clinical health not elsewhere classified @ 100%
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