Nona, Ruth, and Kalo, Eric (2026) Berberine and Metabolic Dysfunction-Associated Steatotic Liver Disease: Hope or Hype? Pharmacology Research & Perspectives, 14 (4). e70300.

Preview

PDF (Published Version) - Published Version Available under License Creative Commons Attribution. Download (360kB) | Preview

Abstract

[Extract] Berberine, an odorless isoquinoline alkaloid derived from the Berberis species, has recently gained significant public attention as a metabolic supplement. Its popularity has been amplified by non-medical messaging primarily through social media, where it is often promoted as “Nature's Ozempic”- a potential alternative to glucagon-like peptide-1 (GLP-1) receptor agonists. This framing is appealing, but it is also potentially misleading. In this commentary, we pose a sharper question: does the current evidence justify viewing berberine as a meaningful adjunct in metabolic dysfunction-associated steatotic liver disease (MASLD), or has enthusiasm outpaced the data?

Item ID:	92624
Item Type:	Article (Commentary)
ISSN:	2052-1707
Copyright Information:	© 2026 The Author(s). Pharmacology Research & Perspectives published by British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Date Deposited:	10 Aug 2026 01:54
FoR Codes:	32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320209 Gastroenterology and hepatology @ 70% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3214 Pharmacology and pharmaceutical sciences > 321402 Clinical pharmacology and therapeutics @ 30%
SEO Codes:	20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 30% 20 HEALTH > 2001 Clinical health > 200104 Prevention of human diseases and conditions @ 40% 20 HEALTH > 2004 Public health (excl. specific population health) > 200411 Overweight and obesity @ 30%
Downloads:	Total: 2 Last 12 Months: 2
	More Statistics