Carranza, Claudia, Ortiz, Lucia, Castellanos, Maria Eugenia, Gonzalez-Reiche, Ana Silvia, Mendizabal-Cabrera, Renata, Khalil, Zain, van DeGuchte, Adriana, Farrugia, Keith, Herrera, Mariana, Mena, Ernesto, Cordon-Rosales, Celia, van Bakel, Harm, and Perez, Daniel R. (2026) Diversity and clinical correlations of SARS-CoV-2 variant during the introduction of the Delta variant in Guatemala. Access Microbiology, 8 (3). 000939.v3.

Preview

PDF (Published Version) - Published Version Available under License Creative Commons Attribution. Download (1MB) | Preview

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomic surveillance is crucial for understanding viral evolution and guiding public health responses. However, many countries, particularly in Central America, have limited sequencing capacity, resulting in scarce and delayed data. This study addresses this gap by analysing 320 SARS-CoV-2 genomes sequenced from a major diagnostic centre in Guatemala City, Guatemala, between April and August 2021. Clade 21J (Delta) was predominant (46.2%), followed by 19B (29.4%) and 20J (Gamma, 6.6%). The most reported symptoms were cough, headache, malaise and myalgia/arthralgia. Among patients infected with the Delta variant, 39.9% reported being contacts from a confirmed case, less than reported by the patients infected with non-Delta variants (53.2%, P=0.017). The proportion of signs and symptoms was similar among these two groups, except for the history of fever, which was increased by ~twofold in the Delta group. This research contributes valuable genomic and epidemiological data to elucidate SARS-CoV-2 variant dynamics in Central America and emphasizes the importance of global genomic surveillance for pandemic preparedness and response.

Item ID:	92610
Item Type:	Article (Research - C1)
ISSN:	2516-8290
Keywords:	Delta variant,Guatemala,severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) surveillance
Copyright Information:	© 2026 The Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
Date Deposited:	13 Jul 2026 01:33
FoR Codes:	42 HEALTH SCIENCES > 4202 Epidemiology > 420202 Disease surveillance @ 100%
SEO Codes:	20 HEALTH > 2004 Public health (excl. specific population health) > 200404 Disease distribution and transmission (incl. surveillance and response) @ 100%
	More Statistics