Blum, Johannes, Neumayr, Andreas, and Lockwood, Diana (2018) Treatment of tegumentary forms of Leishmaniasis. In: Bruschi, Fabrizio, and Gradoni, Luigi, (eds.) The Leishmaniases: Old Neglected Tropical Diseases. Springer International Publishing AG, pp. 191-226.

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Abstract

Choosing a treatment regimen of tegumentary leishmaniasis is influenced by the size, number and location of the lesion(s) but mainly determined by the infecting Leishmania species.

Before treatment, all lesions have to be well documented (measuring the diameter of the ulcer and of the complete lesion plus photo documentation). Since mucosal spread may affect the nasal as well as the oral mucosa, an ear-nose-throat (ENT) examination is indicated and the possibility of CL being part of visceral leishmaniasis (VL) has to be considered.

Treatment options include systemic treatment with antileishmanial drugs, local topical treatment with antileishmanial ointments/creams, local intralesional injection of antileishmanial drugs and local physical treatment (cryotherapy, thermotherapy).

The decision on systemic or local treatment depends on the species, the size, the numbers and the location of the lesions as well as comorbidities. The available antileishmanial drugs, including their dosing, mode of action, mechanism of elimination, adverse effects/toxicity profile and recommendations for treatment monitoring.

Treatment suggestions for cutaneous leishmaniasis are presented for each species. The treatment of mucosal leishmaniasis and leishmaniasis in pregnant women, children and patients with immunosuppression is discussed separately.

Item ID:	92598
Item Type:	Book Chapter (Research - B1)
ISBN:	978-3-319-72385-3
Copyright Information:	© Springer International Publishing AG 2018.
Date Deposited:	21 Sep 2026 01:23
FoR Codes:	42 HEALTH SCIENCES > 4299 Other health sciences > 429999 Other health sciences not elsewhere classified @ 100%
SEO Codes:	20 HEALTH > 2001 Clinical health > 200199 Clinical health not elsewhere classified @ 0% 20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 100%
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