Golledge, Jonathan, and Owens, A. Phillip (2025) Complex role of thrombospondin-1 in aortic aneurysm. Cardiovascular Research, 121 (18). pp. 2827-2829.

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Abstract

[Extract] Aortic aneurysm, characterized by permanent dilation or expansion and weakening of the aortic wall, is an important causes of sudden death due to aortic rupture, which mainly affects older adults or younger individuals within inherited genetic mutations, including those in the transforming growth factor-β (TGFβ) pathway.1,2 Aortic aneurysm is of particular research interest because currently there are no established medical therapies to limit aneurysm progression or rupture and thus identifying drug therapy targets is an urgent focus.1,2

Thrombospondin-1 (TSP-1) is an important extracellular matrix protein that has been linked with an array of functions beyond maintaining tissue integrity, including activating TGFβ.3 TSP-1 has multiple domains with the ability to interact with a range of cell types implicated in aortic remodelling, including monocyte-macrophages, endothelial, and vascular smooth muscle cells (VSMC).3 Plasma and aortic concentrations of TSP-1 have been reported to be higher in patients with aortic dissection than controls.4 Amongst patients with small abdominal aortic aneurysms serum TSP-1 concentrations have been negatively correlated with aneurysm growth during follow-up.5 Thus, TSP-1 might be an important target for a drug therapy for aortic aneurysm.

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