Lin, Yu, Xu, Zhilu, Yeoh, Yun Kit, Tun, Hein Min, Huang, Wenli, Jiang, Wei, Chan, Francis Ka Leung, and Ng, Siew Chien (2023) Combing fecal microbial community data to identify consistent obesity-specific microbial signatures and shared metabolic pathways. iScience, 26 (4). 106476.

Preview

PDF (Published Version) - Published Version Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (5MB) | Preview

Abstract

Obesity is associated with altered gut microbiome composition but data across different populations remain inconsistent. We meta-analyzed publicly available 16S-rRNA sequence datasets from 18 different studies and identified differentially abundant taxa and functional pathways of the obese gut microbiome. Most differentially abundant genera (Odoribacter, Oscillospira, Akkermansia, Alistipes, and Bacteroides) were depleted in obesity, indicating a deficiency of commensal microbes in the obese gut microbiome. From microbiome functional pathways, elevated lipid biosynthesis and depleted carbohydrate and protein degradation suggested metabolic adaptation to high-fat, low-carbohydrate, and low-protein diets in obese individuals. Machine learning models trained on the 18 studies were modest in predicting obesity with a median AUC of 0.608 using 10-fold cross-validation. The median AUC increased to 0.771 when models were trained in eight studies designed for investigating obesity-microbiome association. By meta-analyzing obesity-associated microbiota signatures, we identified obesity-associated depleted taxa that may be exploited to mitigate obesity and related metabolic diseases.

Item ID:	91188
Item Type:	Article (Research - C1)
ISSN:	2589-0042
Copyright Information:	© 2023 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Date Deposited:	23 Apr 2026 02:26
FoR Codes:	32 BIOMEDICAL AND CLINICAL SCIENCES > 3207 Medical microbiology > 320799 Medical microbiology not elsewhere classified @ 100%
SEO Codes:	20 HEALTH > 2004 Public health (excl. specific population health) > 200411 Overweight and obesity @ 100%
Downloads:	Total: 1 Last 12 Months: 1
	More Statistics