de Costa, Alan, Reismann, Marc, and Carvalho, Nuno (2025) The Human Appendix and Antibiotics: Choice and Beneficence. ANZ Journal of Surgery, 95 (11). pp. 2256-2262.

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Abstract

The surgical removal of the appendix has been practiced for more than a hundred years. During this time, improvements in surgical technique, anaesthesia and hospital systems, allied with an increasingly knowledgeable public, have produced remarkable benefits. Recently, Non-Operative Management (NOMA) of some forms of appendicitis with antibiotics has attracted interest and the guarded support of Surgical Societies and Guidelines [1–3]. The biology of the human appendix is incompletely understood, and there is growing awareness that it may not be a mere evolutionary vestige [4, 5]. The consequences of appendicectomy, despite the surgical experience of a hundred years, are unclear, as is the impact of antibiotics on the inflamed appendix and the gut.

Item ID:	91065
Item Type:	Article (Research - C1)
ISSN:	1445-2197
Keywords:	appendicitis, antibiotics, surgery, informed consent
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Copyright Information:	This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non- commercial and no modifications or adaptations are made. © 2025 The Author(s). ANZ Journal of Surgery published by John Wiley & Sons Australia, Ltd on behalf of Royal Australasian College of Surgeons.
Date Deposited:	31 Mar 2026 02:30
FoR Codes:	32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320207 Emergency medicine @ 25% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320226 Surgery @ 50% 42 HEALTH SCIENCES > 4206 Public health > 420699 Public health not elsewhere classified @ 25%
SEO Codes:	20 HEALTH > 2001 Clinical health > 200102 Efficacy of medications @ 50% 20 HEALTH > 2002 Evaluation of health and support services > 200203 Health education and promotion @ 50%
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