Zhao, Huan, Koehler, Anson V., Truarn, Cameron, Bradford, Damien, New, David W., Gasser, Robin B., Sheorey, Harsha, and Bradbury, Richard S. (2025) Reply to “Bridging experimental biology and clinical practice: lessons from autoinfective larvae of Strongyloides stercoralis”. Journal of Clinical Microbiology, 63 (12). e01435-25.

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Abstract

[Extract] We thank the author for their thoughtful commentary on our recent publication, “The fourth-stage autoinfective larva of Strongyloides stercoralis: redescription and diagnostic implications” and for highlighting its broader biological and clinical relevance. We appreciate the opportunity to clarify the scope and intent of our work. Our primary objective was to redescribe autoinfective fourth-stage larvae (L4) recovered from human respiratory specimens, with the aim of supporting laboratory diagnosticians who may encounter these stages in extra-intestinal samples (1). This is particularly relevant in cases of hyperinfection or disseminated strongyloidiasis, where accurate morphological recognition is essential to prevent misidentification, diagnostic confusion, and delays in initiating appropriate treatment (2–4). Accordingly, our discussion was limited to morphological and diagnostic aspects, and we did not explore broader biological implications, as our data did not support such conclusions.

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