Patrick, Desmond, Siddiq, Lubna, and Boyce, Aaron (2025) An Acute Onset Sweet Syndrome After First Vedolizumab Dose in Crohn’s Disease. Inflammatory Bowel Diseases, 31 (12). pp. 3472-3473.

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Abstract

A 40-year-old Caucasian woman with a 21-year history of ileocolonic Crohn’s disease was seen in our inflammatory bowel disease (IBD) clinic with a rash over the neck and torso after her second vedolizumab infusion. She reported developing symptoms of malaise and nausea 2 hours after her first vedolizumab infusion, which was followed by the development of erythematous, non-scaly, painful, pruritic plaques over her posterior neck and torso, 24 hours post-infusion. When reviewed by our dermatology service 7 days after her second infusion, she was noted to have erythematous infiltrated, annular dermal plaques on the posterior and left lateral neck with a few similar plaques on the torso (Figure 1A). Vital signs were within normal limits. Laboratory analysis was only significant for a mildly elevated C-reactive protein (CRP) of 16 mg/L (Normal <5 mg/L). Full blood count, electrolytes, and renal function were normal. Fecal calprotectin was 110 µg/g (Normal <50 µg/g). A 3-mm punch biopsy was taken from the infiltrated dermal plaque on the posterior neck.

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