Evaluation of Natural Dye Extracts from African Plants for the Photooxygenation of α-Terpinene to the Anthelmintic Ascaridole
Enyi, Chinyere Chidimma, Ndukwe, Gloria Ihuoma, Fekarurhobo, Godswill Kuta, and Oelgemoeller, Michael (2026) Evaluation of Natural Dye Extracts from African Plants for the Photooxygenation of α-Terpinene to the Anthelmintic Ascaridole. Organics, 7 (1). 4.
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Abstract
In this study, the singlet oxygen photosensitization potential of three natural African plant extracts was investigated using the photooxygenation of α-terpinene (1). Utilizing visible light, the Carpolobia lutea extract achieved high conversions towards the anthelmintic ascaridole (2) of >60% after 90 min of irradiation, while the extracts of Hibiscus sabdariffa and Justicia secunda failed to induce significant photoreactivity. Quenching using 1,4-diazabicyclo[2.2.2]octane (DABCO) confirmed a singlet oxygen pathway for irradiation with the C. lutea extract. Further separation of the C. lutea extract and subsequent photooxygenation screening established several active fractions for ascaridole generation. Advanced HPLC–MS analyses of these active fractions revealed several photosensitizing constituents. These findings establish C. lutea extract as a sustainable and effective photosensitiser with comparable performance to commercial dyes.
| Item ID: | 90228 |
|---|---|
| Item Type: | Article (Research - C1) |
| ISSN: | 2673-401X |
| Keywords: | Carpolobia lutea; Hibiscus sabdariffa; Justicia secunda; photooxygenation; singlet oxygen; α-terpinene; ascaridole |
| Copyright Information: | © 2026 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license |
| Funders: | James Cook University College of Science and Engineering (JCU) |
| Projects and Grants: | JCU Competitive Research Training Grant 2021 |
| Date Deposited: | 06 Jan 2026 22:17 |
| FoR Codes: | 34 CHEMICAL SCIENCES > 3405 Organic chemistry > 340502 Natural products and bioactive compounds @ 40% 34 CHEMICAL SCIENCES > 3405 Organic chemistry > 340504 Organic green chemistry @ 40% 34 CHEMICAL SCIENCES > 3405 Organic chemistry > 340505 Physical organic chemistry @ 20% |
| SEO Codes: | 28 EXPANDING KNOWLEDGE > 2801 Expanding knowledge > 280105 Expanding knowledge in the chemical sciences @ 100% |
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