Rahman, Tamanna, Das, Simon Kumar, Rahman, Mohammad Lutfar, Ahsan, Md. Emranul, Mimi, Masuda Sultana, Islam, Md. Nushur, Hasan, Md. Tawheed, Pandit, Debasish, and Mazumder, Sabuj Kanti (2025) Nutritional modulation with chitosan nanoparticles and α-tocopherol enhances growth, health and gut histology in butter catfish (Ompok pabda). Discover Food, 5. 325.

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Abstract

This study evaluated the effects of dietary chitosan nanoparticles (CNP), α-tocopherol (VE), and their nanocomposite (CNP-VE) on growth performance, haematology, biochemistry, liver function, immunoglobulin, and intestinal histology of butter catfish (Ompok pabda). Four diets were tested: a control (T1), 5 g kg−1 CNP (T2), 500 mg kg−1 VE (T3), and 5 g kg−1 CNP + 500 mg kg−1 VE (T4). A total of 240 adult fish (13.56 ± 0.33 cm and 14.98 ± 0.78 g) were randomly assigned to the treatments in triplicate groups (n = 20) for a 60-day feeding period. Total length, body weight, feed conversion ratio, and specific growth rate, significantly improved in supplemented groups, with the best performance observed in T4 (p < 0.05). Haematological analysis revealed significant increases in red blood cells, haemoglobin, haematocrit, and MCHC in T4. While total protein, albumin, and globulin remained unchanged, glucose and bilirubin levels were significantly lower in T4, indicating improved metabolic status. IgM level was enhanced across treatments, with the greatest increase in T4. Histological examination showed improved intestinal structure in T4, including uniform goblet cell distribution and well-formed villi. These findings suggest that combined supplementation of CNP and VE has a synergistic effect in enhancing growth, physiological health, immunity, and gut morphology in O. pabda under intensive culture.

Item ID:	90107
Item Type:	Article (Research - C1)
ISSN:	2371-4286
Keywords:	Chitosan-vitamin E nanocomposite, Haematology, Immunity, Liver function, Ompok Pabda
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Copyright Information:	© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.
Date Deposited:	28 Jan 2026 23:33
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