Linalool exerts antiemetic effects via dopaminergic and serotonergic pathways: Evidence from chick model and molecular docking
Fahmi, Abdullah Al, Akter, Khadija, Rakib, Imam Hossen, Hossain, Sakib, Alkhathami, Ali G., Al Hasan, Md Sakib, Hossan, Rakib, Ara, Iffat, Rahaman, Md. Mizanur, and Islam, Muhammad Torequl (2025) Linalool exerts antiemetic effects via dopaminergic and serotonergic pathways: Evidence from chick model and molecular docking. Naunyn-Schmiedebergs Archives of Pharmacology, 399. pp. 4401-4411.
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Abstract
Linalool (LIN), a naturally occurring monoterpene alcohol found in aromatic plants, exhibits diverse pharmacological properties, yet its antiemetic potential remains underexplored. In this study, we investigated the antiemetic efficacy of LIN using both in vivo and in silico approaches. Emesis was induced in chicks via oral administration of copper sulfate pentahydrate (50 mg/kg), and LIN was tested at doses of 25, 50, and 100 mg/kg. Its effects were compared against the standard antiemetics domperidone (DOM, 7 mg/kg) and ondansetron (OND, 5 mg/kg). Results demonstrated that LIN at 100 mg/kg significantly prolonged the emetic latency and reduced the number of retches. Notably, co-administration of LIN (50 mg/kg) with DOM significantly (p < 0.05) produced the most potent effect, yielding the highest latency and lowest number of retches, reflecting a synergistic interaction. Molecular docking studies revealed a strong binding affinity of LIN to the dopamine D2 receptor (− 6.4 kcal/mol) and moderate binding to the 5-HT3 receptor (− 5.3 kcal/mol), suggesting involvement of both dopaminergic and serotonergic mechanisms. These findings collectively indicate that LIN possesses significant antiemetic activity and may offer a plant-derived alternative for emesis control.
| Item ID: | 90056 |
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| Item Type: | Article (Research - C1) |
| ISSN: | 1432-1912 |
| Keywords: | 5HT3 receptor, Antiemetic activity, D2 receptor, Linalool, Molecular docking |
| Copyright Information: | © The Author(s) 2025. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
| Date Deposited: | 19 Aug 2026 03:48 |
| FoR Codes: | 32 BIOMEDICAL AND CLINICAL SCIENCES > 3214 Pharmacology and pharmaceutical sciences > 321401 Basic pharmacology @ 100% |
| SEO Codes: | 20 HEALTH > 2001 Clinical health > 200102 Efficacy of medications @ 100% |
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