Kinobe, Robert T., Picard, Jacqueline, and Fitzegerald, Isabella (2025) Trends In Antimicrobial Resistance For Pseudomonas Isolates From Dogs. In: Vet Science Week 2025 Presentations. From: ANZCVS Vet Science Week 2025, 23-26 July 2025, Gold Coast, QLD, Australia.

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Abstract

Pseudomonas aeruginosa and Pseudomonas fluorescens are associated with many infections, and are intrinsically resistant to many antibiotics. Among effective drugs against these bacteria, only fluoroquinolones can be administered orally, are used extensively, and this selects for resistance.1,2 We hypothesised that canine Pseudomonas isolates exhibited significantly higher incidences of resistance against fluoroquinolones compared to other anti-Pseudomonas antibiotics. A systematic review and meta-analyses were done to determine incidences and distribution patterns of antimicrobial resistance in Pseudomonas isolates from canine infections. Extracted data were stratified by infection, year of isolation, geographical location and tested antibiotics. Statistical evaluations were done using Chi-square tests and analysis of variance. Data were extracted from 73 studies with antimicrobial susceptibility tests based on a total of 9911 isolates. In these isolates, 47.8% were cases of otitis while mixed, skin and systemic infections contributed 52.2%. Relative to carbapenems, tested isolates exhibited significantly higher incidences of resistance to fluroquinolones (OR = 7.1, 95% CI 6.35, 7.84; Figure 1). The highest incidence of resistance was against enrofloxacin with resistance in 53%, 49% and 29% of isolates from otitis, respiratory infections and ocular conditions respectively. These data imply a higher selection pressure for resistance against fluoroquinolones; this may be exacerbated by the empirical use of antibiotics such as enrofloxacin, as exemplified by its use in some cases of otitis externa.3 For clinical cases with suspected involvement of Pseudomonas spp., caution should be exercised in using fluoroquinolones empirically.

Item ID:	89621
Item Type:	Conference Item (Presentation)
Date Deposited:	17 Nov 2025 23:54
FoR Codes:	30 AGRICULTURAL, VETERINARY AND FOOD SCIENCES > 3009 Veterinary sciences > 300904 Veterinary diagnosis and diagnostics @ 40% 30 AGRICULTURAL, VETERINARY AND FOOD SCIENCES > 3009 Veterinary sciences > 300911 Veterinary pharmacology @ 60%
SEO Codes:	20 HEALTH > 2001 Clinical health > 200102 Efficacy of medications @ 100%
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