Kratina, Sarah, Strike, Carol, Schwartz, Robert, Nayfeh, Ayah, Jopling, Sydney, Lo, Chris, and Rush, Brian (2025) A scoping review of variations in psychedelic interventions for psychological suffering associated with the end of life. Social Science and Medicine. (In Press)

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Abstract

Background Psychedelic substances are recognized for their potential to ease psychological suffering linked to end-of-life issues, yet policy remains restrictive. The wide range of both substances and therapeutic approaches used in end-of-life populations has not been adequately covered by reviews to date.

Aim To identify and learn from the variety that exists within the research on therapeutic psychedelic interventions reported in populations coping with psychological suffering associated with life-threatening illness and the end of life itself.

Methods Following Arksey and O’Malley’s (2005) framework for scoping reviews, updated methodological guidance, and the Preferred Reporting Items for Systematic Review and Meta-Analyses extension for scoping reviews guideline, data extracted from selected studies covered intervention details, substances used, participant characteristics, measured outcomes, and theorized mechanisms.

Results Fifty-nine studies on six types of psychedelic substances for end-of-life issues were identified, with case study designs most common. Interventions were categorized into dosing alone, preparation/dosing/integration, and dosing with any psychotherapeutic support not provided within the tripartite model. Most studies reported challenging experiences, with a large proportion considering them therapeutic. Outcome measures spanned biopsychosocial-spiritual domains, with affective and cognitive-affective sub-domains most often assessed; neurobiological mechanisms were reported in 54% of studies, psychological in 51%, and spiritual in 44%, indicating diverse therapeutic processes.

Conclusion There is extraordinary variety in how psychedelics are studied to address the experience of psychological suffering associated with end-of-life concerns. The variability in psychedelic research reflects an early and exploratory phase, differences in beliefs about how therapeutic psychedelic interventions effect change, and the genuine richness in possibilities for therapeutic psychedelic intervention.

Item ID:	88908
Item Type:	Article (Research - C1)
ISSN:	1873-5347
Copyright Information:	© 2025 The Authors. Published by Elsevier Ltd.Attribution-NonCommercial-NoDerivatives 4.0 International CC BY-NC-ND 4.0 Deed
Date Deposited:	13 Oct 2025 22:43
FoR Codes:	42 HEALTH SCIENCES > 4203 Health services and systems > 420316 Palliative care @ 40% 52 PSYCHOLOGY > 5202 Biological psychology > 520205 Psychopharmacology @ 30% 44 HUMAN SOCIETY > 4410 Sociology > 441007 Sociology and social studies of science and technology @ 30%
SEO Codes:	28 EXPANDING KNOWLEDGE > 2801 Expanding knowledge > 280112 Expanding knowledge in the health sciences @ 30% 20 HEALTH > 2003 Provision of health and support services > 200309 Palliative care @ 40% 20 HEALTH > 2004 Public health (excl. specific population health) > 200409 Mental health @ 30%
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