Insights into Infant Strongyloidiasis, Papua New Guinea
Zhao, Huan, Haidamak, Juciliane, Noskova, Eva, Ilik, Vladislav, Pafčo, Barbora, Ford, Rebecca, Masiria, Geraldine, Maure, Tobias, Kotale, Nichola, Pomat, William, Gordon, Catherine, Navarro, Severine, Horwood, Paul F., Constantinoiu, Constantin, Greenhill, Andrew R., and Bradbury, Richard S. (2025) Insights into Infant Strongyloidiasis, Papua New Guinea. Emerging Infectious Diseases, 31 (9). pp. 1793-1801.
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Abstract
The human-infecting parasite Strongyloides fuelleborni subspecies kellyi has been reported from the island of New Guinea. We analyzed fecal DNA extracts (n = 164) from 19 infants in Papua New Guinea by using Strongyloides real-time PCR and undertook metabarcoding of cox1 and 18S rRNA hypervariable regions I and IV loci. Eight infants were infected with Strongyloides spp.; 7 were infected with S. fuelleborni subsp. fuelleborni and 1 with a Strongyloides sp. previously misattributed to S. fuelleborni subsp. kellyi. Phylogenetic and haplotyping analyses indicated S. fuelleborni in Papua New Guinea belongs to the Indochina subclade of S. fuelleborni subsp. fuelleborni and is not a unique subspecies. We report molecular evidence of S. fuelleborni subsp. fuelleborni infection in humans in the Pacific. Our findings also demonstrate the potential co-existence of an undescribed human-infecting Strongyloides sp. on the island of New Guinea, indicating a need for renewed clinical and epidemiologic investigations into infant strongyloidiasis.
| Item ID: | 88792 |
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| Item Type: | Article (Research - C1) |
| ISSN: | 1080-6059 |
| Copyright Information: | All materials published in Emerging Infectious Diseases, including text, figures, tables, and photographs, are in the public domain and can be reprinted or used without permission with proper citation. All content is freely available without charge to the user or their institution. In accordance with the Budapest Open Access InitiativeExternal Link definition of open access, users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. Because the journal is in the public domain, its usage policy also conforms to conditions set forth by Creative Commons. |
| Funders: | National Health and Medical Research Council of Australia (NHMRC). |
| Projects and Grants: | NHMRC APP119446 |
| Date Deposited: | 29 Oct 2025 02:34 |
| FoR Codes: | 32 BIOMEDICAL AND CLINICAL SCIENCES > 3207 Medical microbiology > 320704 Medical parasitology @ 100% |
| SEO Codes: | 21 INDIGENOUS > 2111 Pacific Peoples health > 211199 Pacific Peoples health not elsewhere classified @ 50% 20 HEALTH > 2004 Public health (excl. specific population health) > 200404 Disease distribution and transmission (incl. surveillance and response) @ 50% |
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