Antidiabetic medicinal plants of Indonesia: their in silico, in vitro, in vivo and clinical trial studies
Nugraha, Ari Satia, Kintoko, Kintoko, Putri, Chintya Permata Zahky Sukrisno, Az-Zahra, Fatima, Firli, Lilla Nur, Rani, Dinar Mutia, Purnomo, Yoshinta Debby, Nguyen, Phuong Thuy Viet, Puspitasari, Rara Merinda, Hartati, Tri, Triatmoko, Bawon, Pratama, Antonious Nugraha Widhi, Wahyuni, Dinar Sari Cahyaningrum, Muliasari, Handa, Keller, Paul Anthony, and Wangchuk, Phurpa (2025) Antidiabetic medicinal plants of Indonesia: their in silico, in vitro, in vivo and clinical trial studies. Phytochemistry reviews, 25. pp. 1581-1619.
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Abstract
The tropical islands of Indonesia house the second largest biodiversity in the world. For generations, indigenous communities have relied on medicinal plants to treat various ailments, including diabetes. However, no comprehensive systematic review has been conducted to consolidate research progress in this area. This review aims to investigate and summarize the current research landscape on antidiabetic medicinal plants in Indonesia. Data collection, collation and analysis were performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Relevant publications on the antidiabetic evaluation of Indonesian medicinal plants were retrieved from leading scientific databases, including Scifinder® and Garuda, yielding a total of 108 eligible articles. Several notable compound screening studies identified bioactive phytochemicals with significant antidiabetic potential, such as quinine as a SIRT1 activator, prunetin as an aldose reductase inhibitor, gallic acid as a pancreatic α-amylase (PPA) inhibitor, oleanolic acid as a PTP1B inhibitor, and 3,4,5-tri-O-caffeoylquinic acid methyl ester as an α-glucosidase inhibitor. Additionally, clinical investigations and community-based trials reported significant blood glucose-lowering effects from botanical extracts including Piper crocatum, Moringa oleifera, and Curcuma xanthorrhiza in diabetic patients. Recognizing the therapeutic potential of indigenous botanicals, the Indonesian government has intensified its support for the development of scientifically standardized herbal medicines aimed at diabetes treatment, positioning them as part of the country’s integrated healthcare system.
| Item ID: | 88684 |
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| Item Type: | Article (Research - C1) |
| ISSN: | 1572-980X |
| Keywords: | Antidiabetic, Clinical, In silico, In vitro, in vivo, Indonesian herbal medicine, Indonesian medicinal plants, Phytopharmaceuticals |
| Copyright Information: | © The Author(s) 2025. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
| Date Deposited: | 19 Jun 2026 06:23 |
| FoR Codes: | 34 CHEMICAL SCIENCES > 3405 Organic chemistry > 340505 Physical organic chemistry @ 100% |
| SEO Codes: | 20 HEALTH > 2001 Clinical health > 200102 Efficacy of medications @ 100% |
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