Is There Magic in the Oldest Diabetes Drug If You Have an Abdominal Aortic Aneurysm

Golledge, Jonathan (2025) Is There Magic in the Oldest Diabetes Drug If You Have an Abdominal Aortic Aneurysm. European Journal of Vascular and Endovascular Surgery, 70 (4). p. 426.

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DOI: 10.1016/j.ejvs.2025.05.001

View at Publisher Website: https://doi.org/10.1016/j.ejvs.2025.05.0...

Abstract

[Extract] In this issue of the European Journal of Vascular and Endovascular Surgery, Eilenberg and colleagues report the outcome of the first trial of metformin in patients with an abdominal aortic aneurysm (AAA) who do not have diabetes.1 The trial was conducted to test whether metformin could limit AAA growth and reduce the need for AAA repair or risk of aneurysm rupture in patients with a small AAA. Diabetes has consistently been associated with reduced prevalence and growth of AAA, and observational studies have suggested this may in part result from the diabetes drug metformin inhibiting aortic wall degeneration.2 Due to these observational findings, four investigator led randomised controlled trials were initiated.3


Item ID:	88520
Item Type:	Article (Short Note)
ISSN:	1532-2165
Copyright Information:	2025 European Society for Vascular Surgery. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
Date Deposited:	06 May 2026 06:10
FoR Codes:	32 BIOMEDICAL AND CLINICAL SCIENCES > 3201 Cardiovascular medicine and haematology > 320101 Cardiology (incl. cardiovascular diseases) @ 100%
SEO Codes:	20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 100%
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