Pregnancy in women with mitochondrial disease—A literature review and suggested guidance for preconception and pregnancy care
Hui, Lisa, Hayman, Pema, Buckland, Ali, Fahey, Michael C., Mackey, David A., Mallett, Andrew J., Schweitzer, Daniel R., Stuart, Clare P., Yau, Wai Yan, and Christodoulou, John (2025) Pregnancy in women with mitochondrial disease—A literature review and suggested guidance for preconception and pregnancy care. Australian and New Zealand Journal of Obstetrics and Gynaecology, 65 (1). pp. 30-36.
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Abstract
Mitochondrial donation to reduce the risk of primary mitochondrial disease transmission from mother to child is now permitted under Australian law as part of a clinical trial. The energy demands of pregnancy have the potential to worsen mitochondrial disease symptoms and severity in affected women. We conducted a systematic literature review on mitochondrial disease in pregnancy; five cohort studies and 19 case reports were included. For many women with mitochondrial disease, pregnancy does not have a negative effect on health status. However, serious adverse outcomes may occur. We provide suggested guidelines for preconception counselling and antenatal care.
| Item ID: | 88366 |
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| Item Type: | Article (Research - C1) |
| ISSN: | 1479-828X |
| Keywords: | assisted reproductive techniques, genetics, mitochondrial disease, pregnancy, pregnancy complications |
| Copyright Information: | © 2024 The Author(s). Australian and New Zealand Journal of Obstetrics and Gynaecology published by John Wiley & Sons Australia, Ltd on behalf of Royal Australian and New Zealand College of Obstetricians and Gynaecologists. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| Date Deposited: | 13 Apr 2026 07:18 |
| FoR Codes: | 32 BIOMEDICAL AND CLINICAL SCIENCES > 3215 Reproductive medicine > 321502 Obstetrics and gynaecology @ 100% |
| SEO Codes: | 20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 100% |
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