Sandhu, Geeta, Adattini, Josephine, Armstrong Gordon, Evangeline, O'Neill, Niamh, Bagnis, Corrinne, Boddy, Alan V., Chambers, Pinkie, Flynn, Alex, Hamilton, Brett, Ibrahim, Karim, Johnson, David W., Karapetis, Christos, Kelly, Aisling, Kerr, Kimberley Ann, Kichenadasse, Ganessan, Kliman, David S., Kurkard, Craig, Liauw, Winston, Lucas, Catherine, Mallett, Andrew J., Malyszko, Jolanta, McCaughan, Georgia, Michael, Michael, Mirkov, Sanja, Morris, Emma, Pollock, Carol A., Roberts, Darren M., Routledge, David J., Scuderi, Carla, Shingleton, Julia, Shortt, Jake, Siderov, Jim, Sprangers, Ben, Stein, Brian N., Tey, Amanda, Webber, Kate, Wichart, Jenny, Wong, Rachel, and Ward, Robyn L. (2025) Integrating International Consensus Guidelines for Anticancer Drug Dosing in Kidney Dysfunction (ADDIKD) into everyday practice. EClinicalMedicine, 82. 103161.

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Abstract

Part 2 of the International Consensus Guideline on Anticancer Drug Dosing in Kidney Dysfunction (ADDIKD) offers drug-specific consensus recommendations based on both evidence and practical experience. These recommendations build upon the kidney function assessment and classification guidelines established in Part 1 of ADDIKD. Here we illustrate how dosing recommendations differ between ADDIKD and existing guidance for four commonly used drugs: methotrexate, cisplatin, carboplatin and nivolumab. We then describe how the recommendations can be distilled into practice points for methotrexate and cisplatin. While ADDIKD is a significant improvement from previous guidelines, adoption of this new guideline requires further endorsement from key external stakeholders, ‘change championing’ by clinicians locally and encouraging its integration into existing reference sources, clinical trial protocols and electronic prescribing systems. Funding: Development of the ADDIKD guideline is funded by the NSW Government as part of the Cancer Institute NSW and received no funding from external commercial sources.

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