Two-Stage Revision Total Knee Arthroplasty for Melioidosis Prosthetic Joint Infection: A Case Report
Dadwal, Parvati, Samaraweera, Samitha, Smith, Jon, De Silva, Janath, Smith, Simon, and Hanson, Josh (2025) Two-Stage Revision Total Knee Arthroplasty for Melioidosis Prosthetic Joint Infection: A Case Report. JBJS Case Connectos, 15 (2). e25.00051.
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Abstract
CASE: Burkholderia pseudomallei can kill up to 40% of individuals who develop symptoms, but the pathogen has rarely been reported as a cause of prosthetic joint infection (PJI). We report a case of a woman with cultured-confirmed B. pseudomallei knee PJI who survived her infection and had excellent functional recovery after a 2-stage revision, 8 weeks of intravenous ceftazidime followed by 6 months of oral trimethoprim-sulfamethoxazole. Eight years later, she had no postoperative complications, no relapse, and an Oxford Knee Score of 34. CONCLUSION: B. pseudomallei PJI is rare but life-threatening. Two-stage revision and long-term antibiotic therapy are recommended to effect cure.
| Item ID: | 88187 |
|---|---|
| Item Type: | Article (Research - C1) |
| ISSN: | 2160-3251 |
| Keywords: | melioidosis, prosthetic joint infection |
| Copyright Information: | © 2025 by The Journal of Bone and Joint Surgery, Incorporated. |
| Date Deposited: | 05 Nov 2026 01:34 |
| FoR Codes: | 32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320216 Orthopaedics @ 33% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320226 Surgery @ 34% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320211 Infectious diseases @ 33% |
| SEO Codes: | 20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 100% |
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