Andreazza, Ana C., Barros, L. Felipe, Behnke, Alexander, Ben-Shachar, Dorit, Berretta, Sabina, Chouinard, Virginie Anne, Do, Kim, Edwin Thanarajah, Sharmili, Ehrenreich, Hannelore, Falkai, Peter, Ford, Judith, Freyberg, Zachary, Gilbert-Jaramillo, Javier, Glausier, Jill R., Goyal, Manu S., Hahn, Margaret, Herculano-Houzel, Suzana, Hofmann, David, Kolassa, Iris Tatjana, Mack, Matthias, Mavioglu, R. Nehir, McCullumsmith, Robert, Milaneschi, Yuri, Molina, Anthony J.A., Mujica-Parodi, Lilianne, Öngür, Dost, Paulus, Martin, Peleg-Raibstein, Daria, Perry, Ben, Picard, Martin, Pillinger, Toby, Rae, Caroline, Rothman, Douglas, Sarnyai, Zoltan, Steiner, Johann, Upthegrove, Rachel, Vernon, Anthony C., Wall, Melanie, and Weistuch, Corey (2025) Brain and body energy metabolism and potential for treatment of psychiatric disorders. Nature Mental Health, 3 (7). pp. 763-771.

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Abstract

Brain function is critically dependent on energy metabolism. Research over the past half century has provided many insights into energy production and utilization in the brain, and identified ways that it can be improved in brain disorders. A parallel literature indicates that major aberrations exist in brain bioenergetics in neuropsychiatric disorders. Targeting bioenergetic abnormalities may be an efficacious approach to treatment for these conditions. In this Perspective, we provide a survey of the relevant literature on these topics and sketch the outlines of a research agenda to maximize the impact of future research and treatment interventions.

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