Nicholls, Kathleen, and Mallett, Andrew J. (2025) Genetic Kidney Disease Across the Lifespan – Emerging Insights From Clinical Genomics in Older People. Kidney International Reports, 10 (8). pp. 2548-2550.

Preview

PDF (Published Version) - Published Version Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (357kB) | Preview

Abstract

[Extract] The growth in understanding of genetic kidney disease has burgeoned over the past several decades. This has been punctuated by key moments of reflection and discovery, leading to an increasingly sophisticated knowledge of gene and disease relationships. In the recent past, this has been enabled and accelerated substantially by the implementation of genomic technologies, first in research and now in clinical practice.1,2 With increased accessibility and uptake3 have come important insights, including those recently presented by Elhassan et al.4 The longstanding perception that human disease of a monogenic etiology is primarily prevalent within pediatric populations was also the initial impression in nephrology. Genetic kidney disease is now, however, being demonstrated to be a diagnosis of potential interest for people affected by kidney disease of all ages,5,6 now clearly including those of older age. This is perhaps because of the inherent diversity of phenotypes, inheritance patterns, multigene interactions, and lifespan dynamics that are becoming characteristic of genetic kidney disease (Figure 1).

Actions (Repository Staff Only)

Item Control Page