Blood volume reduction due to rapid plasma loss after birth in preterm piglets
Nguyen, Tam M.T., Morwood, Holly, Bakrania, Bhavisha A., Miller, Stephanie M., Bjorkman, Stella T., Lingwood, Barbara E., Wright, Ian M.R., and Eiby, Yvonne A. (2024) Blood volume reduction due to rapid plasma loss after birth in preterm piglets. Pediatric Research, 96 (7). pp. 1693-1698.
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Abstract
Background: Understanding changes in blood volume after preterm birth is critical to preventing cardiovascular deterioration in preterm infants. The aims were to determine if blood volume is higher in preterm than term piglets and if blood volume changes in the hours after birth. Methods: Paired blood volume measurements were conducted in preterm piglets (98/115d gestation, ~28wk gestation infant) at 0.5–5 h (n = 12), 0.5-9 h (n = 44) and 5–11 h (n = 7) after birth, and in a term cohort at 0.5–9 h (n = 40) while under intensive care. Results: At 30 min after birth, blood volume was significantly lower in preterm piglets compared to term piglets. By 9 h after birth, blood volume had reduced by 18% in preterm piglets and 13% in term piglets. By 5–9 h after birth, preterm piglets had significantly lower blood volumes than at term (61 ± 10 vs. 76 ± 11 mL/kg). Conclusions: In contrast to clinical resources, preterm piglets have a lower blood volume than at term. Substantial reductions in blood volume after birth leave some preterm piglets hypovolemic. If this also occurs in preterm infants, this may have important clinical consequences. Modern studies of blood volume changes after birth are essential for improving preterm outcomes. Impact: Preterm piglets do not have a higher blood volume than their term counterparts, in contrast to current clinical estimates. Rapid reduction in blood volume after birth leads to hypovolemia in some preterm piglets. There is a critical need to understand blood volume changes after birth in preterm infants in order to improve clinical management of blood volume.
| Item ID: | 87136 |
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| Item Type: | Article (Research - C1) |
| ISSN: | 1530-0447 |
| Copyright Information: | Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ |
| Funders: | National Health and Medical Research Council (NHMRC) |
| Projects and Grants: | NHMRC APP1187505 |
| Date Deposited: | 05 Nov 2025 23:20 |
| FoR Codes: | 32 BIOMEDICAL AND CLINICAL SCIENCES > 3213 Paediatrics > 321303 Neonatology @ 100% |
| SEO Codes: | 20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 50% 20 HEALTH > 2005 Specific population health (excl. Indigenous health) > 200506 Neonatal and child health @ 50% |
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