Cabral, Reniel, and Lim, May T. (2010) Polarity-Driven Geometrical Cluster Growth Model of Budding Yeast. International Journal of Modern Physics C, 21 (9). pp. 1169-1182.

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Abstract

We present a polarity-driven activator-inhibitor model of budding yeast in a two-dimensional medium wherein impeding metabolites secretion (or growth inhibitors) and growth directionality are determined by the local nutrient level. We found that colony size and morphological features varied with nutrient concentration. A branched-type morphology is associated with high impeding metabolite concentration together with a high fraction of distal budding, while opposite conditions (low impeding metabolite concentration, high fraction of proximal budding) promote Eden-type patterns. Increasing the anisotropy factor (or polarity) produced other spatial patterns akin to the electrical breakdown under varying electric field. Rapid changes in the colony morphology, which we conjecture to be equivalent to a transition from an inactive quiescent state to an active budding state, appeared when nutrients were limited.

Item ID:	86979
Item Type:	Article (Research - C1)
ISSN:	1793-6586
Keywords:	Polarity as growth strategy, yeast growth modeling, geometrical cluster growth, pattern formation, agent-based modeling
Copyright Information:	© World Scientific Publishing Company.
Date Deposited:	22 Aug 2025 04:00
FoR Codes:	51 PHYSICAL SCIENCES > 5199 Other physical sciences > 519901 Complex physical systems @ 100%
SEO Codes:	28 EXPANDING KNOWLEDGE > 2801 Expanding knowledge > 280120 Expanding knowledge in the physical sciences @ 100%
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