Obeid, S., and Hebbard, L. (2013) The role of adiponectin in inflammatory bowel disease. Journal of Gastroenterology and Hepatology, 28 (Suppl. 2). pp. 15-16.

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Abstract

Introduction: Inflammatory bowel disease, collectively consisting of Crohn’s Disease and Ulcerative Colitis (UC), affects 5 million people worldwide, with over 75,000 cases residing in Australia. UC is primarily characterised by abdominal pain and gastrointestinal bleeding, and is associated with increased risks of colorectal cancer. Adiponectin (APN), an adipocytokine is known to have anti-inflammatory effects, and its interactions with the receptor, T-cadherin, are yet to be elucidated in the context of UC.

Materials and methods: Adiponectin and T-cadherin knockout mice were given dextran sulphate sodium (DSS)-induced colitis, and compared to wild type mice. HCT116 colonic epithelial cells were also used for in vitro experiments.

Results: Our studies showed that both APN and T-cadherin knockout mice are highly susceptible to colitis, suggesting that the interaction between both is of importance in potentially maintaining the integrity of the colonic epithelial barrier. T-cadherin knockout mice presented with severe rectal bleeding and weight loss, following DSS treatment. APN null mice express decreased T-cadherin colonic protein, following treatment with DSS, as well as a downregulation of PI3k. This could be attributed to LPS infiltration, as our in vitro data suggests an LPS mediated downregulation of T-cadherin. We anticipate that these experiments will be a starting point for investigations pertaining to the role of the gut biota and its potential pathogenic properties in contributing to inflammatory bowel disease, namely with respect to the role of T-cadherin in maintaining a healthy gut barrier function.

Item ID:	86256
Item Type:	Article (Abstract)
ISSN:	1440-1746
Copyright Information:	© 2013 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd.
Date Deposited:	21 Jul 2025 23:27
FoR Codes:	32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320209 Gastroenterology and hepatology @ 100%
SEO Codes:	20 HEALTH > 2001 Clinical health > 200101 Diagnosis of human diseases and conditions @ 100%
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