Hebbard, Lionel, Ramezani-Moghadam, Medhi, Wang, Jianhua, and George, Jacob (2012) Adiponectin mediates hepatic stellate cell invasion through TIMP-1 and CD63 regulation of FAK activity. Journal of Gastroenterology and Hepatology, 27 (Suppl. 4). pp. 6-7.

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Abstract

Background: Adiponectin (ADN) is an adipocytokine that inhibits hepatic stellate cell (HSCs) proliferation, migration and invasion, and can promote their apoptosis in vitro. We find that adiponectin through AMPK stimulates HSCs to release the matrix metalloproteinase inhibitor, TIMP-1. Traditionally, TIMP-1 has been associated with the progression of liver fi brosis. Thus, the induction of TIMP-1 by adiponectin would appear to be counter-intuitive to its published anti-fibrotic effects. TIMP-1 has been recently reported to inhibit focal adhesion kinase (FAK) phosphorylation, a marker of decreased cellular invasion and migration. Additionally, CD63 has been reported to be a novel binding partner for TIMP-1. Thus, the aim of this study was to investigate whether ADN stimulated TIMP-1 is associated with altered FAK activity in rat HSCs and in an in vivo model of liver fibrosis.

Item ID:	86253
Item Type:	Article (Abstract)
ISSN:	1440-1746
Copyright Information:	© 2012 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd.
Date Deposited:	24 Jul 2025 23:33
FoR Codes:	32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320209 Gastroenterology and hepatology @ 100%
SEO Codes:	20 HEALTH > 2001 Clinical health > 200101 Diagnosis of human diseases and conditions @ 100%
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