Ramezani-Moghadam, M., Wang, J., Brymora, J., George, J., and Hebbard, L. (2011) Adiponectin mediates hepatic stellate cell invasion through TIMP-1 regulation of focal adhesion kinase activity. Journal of Gastroenterology and Hepatology, 26 (Suppl. 4). p. 12.

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Abstract

Adiponectin (ADN) is an adipocytokine that inhibits the proliferation, migration/invasion and promotes the apoptosis of activated HSCs in vitro. We find that adiponectin through AMPK stimulates HSCs to release the matrix metalloproteinase inhibitor, TIMP-1. Traditionally, TIMP-1 has been associated with the progression of liver fibrosis. Thus, the induction of TIMP-1 by adiponectin would appear to be counter-intuitive to its published anti-fibrotic effects. TIMP-1 has recently reported to inhibit focal adhesion kinase (FAK) phosphorylation by binding to CD63. Furthermore, reduced p-FAK levels in a number of cell types have been associated with decreased migration/invasion. Thus, the aim of this study was to investigate whether ADN stimulated TIMP-1 levels are associated with altered FAK activity in activated rat HSCs.

Item ID:	86249
Item Type:	Article (Abstract)
ISSN:	1440-1746
Copyright Information:	© 2011 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing.
Date Deposited:	24 Jul 2025 23:38
FoR Codes:	32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320209 Gastroenterology and hepatology @ 100%
SEO Codes:	20 HEALTH > 2001 Clinical health > 200101 Diagnosis of human diseases and conditions @ 100%
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