A systematic review on the role of gut microbiome in inflammatory bowel disease: Spotlight on virome and plant metabolites
Rahaman, Md. Mizanur, Wangchuk, Phurpa, and Sarker, Subir (2025) A systematic review on the role of gut microbiome in inflammatory bowel disease: Spotlight on virome and plant metabolites. Microbial Pathogenesis, 205. 107608.
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Abstract
Inflammatory bowel diseases (IBD), including ulcerative colitis and Crohn's disease, arise from various factors such as dietary, genetic, immunological, and microbiological influences. The gut microbiota plays a crucial role in the development and treatment of IBD, though the exact mechanisms remain uncertain. Current research has yet to definitively establish the beneficial effects of the microbiome on IBD. Bacteria and viruses (both prokaryotic and eukaryotic) are key components of the microbiome uniquely related to IBD. Numerous studies suggest that dysbiosis of the microbiota, including bacteria, viruses, and bacteriophages, contributes to IBD pathogenesis. Conversely, some research indicates that bacteria and bacteriophages may positively impact IBD outcomes. Additionally, plant metabolites play a crucial role in alleviating IBD due to their anti-inflammatory and microbiome-modulating properties. This systematic review discusses the role of the microbiome in IBD pathogenesis and evaluates the potential connection between plant metabolites and the microbiome in the context of IBD pathophysiology.
| Item ID: | 86165 |
|---|---|
| Item Type: | Article (Research - C1) |
| ISSN: | 1096-1208 |
| Copyright Information: | © 2025 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/ ). |
| Funders: | Australian Research Council (ARC) |
| Projects and Grants: | ARC Discovery Early Career Researcher Award (grant number DE200100367) |
| Date Deposited: | 29 Jul 2025 02:37 |
| FoR Codes: | 31 BIOLOGICAL SCIENCES > 3107 Microbiology > 310702 Infectious agents @ 100% |
| SEO Codes: | 20 HEALTH > 2001 Clinical health > 200101 Diagnosis of human diseases and conditions @ 100% |
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