Kalo, Eric, Read, Scott, and Ahlenstiel, Golo (2021) Targeting Gut–Liver Axis for Treatment of Liver Fibrosis and Portal Hypertension. Livers, 1 (3). pp. 147-179.

Preview

PDF (Published Version) - Published Version Available under License Creative Commons Attribution. Download (2MB) | Preview

Abstract

Antifibrotic therapies for the treatment of liver fibrosis represent an unconquered area of drug development. The significant involvement of the gut microbiota as a driving force in a multitude of liver disease, be it pathogenesis or fibrotic progression, suggest that targeting the gut–liver axis, relevant signaling pathways, and/or manipulation of the gut’s commensal microbial composition and its metabolites may offer opportunities for biomarker discovery, novel therapies and personalized medicine development. Here, we review potential links between bacterial translocation and deficits of host-microbiome compartmentalization and liver fibrosis that occur in settings of advanced chronic liver disease. We discuss established and emerging therapeutic strategies, translated from our current knowledge of the gut–liver axis, targeted at restoring intestinal eubiosis, ameliorating hepatic fibrosis and rising portal hypertension that characterize and define the course of decompensated cirrhosis.

Item ID:	86139
Item Type:	Article (Research - C1)
ISSN:	2673-4389
Keywords:	liver fibrosis; portal hypertension; microbiota; cirrhosis; chronic liver disease; gut–liver axis; bacterial translocation; hepatic macrophages; PRRs; TLRs
Related URLs:	Publisher
Copyright Information:	© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)
Date Deposited:	16 Jul 2025 23:15
FoR Codes:	32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320209 Gastroenterology and hepatology @ 40% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3214 Pharmacology and pharmaceutical sciences > 321402 Clinical pharmacology and therapeutics @ 30% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320203 Clinical microbiology @ 30%
SEO Codes:	20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 40% 20 HEALTH > 2001 Clinical health > 200199 Clinical health not elsewhere classified @ 30% 20 HEALTH > 2001 Clinical health > 200102 Efficacy of medications @ 30%
	More Statistics