Kalo, Eric, Read, Scott, Baig, Asma, Marshall, Kate, Ma, Wai-See, Crowther, Helen, Gofton, Cameron, Lynch, Kate D., Sood, Siddharth, Holmes, Jacinta, Lubel, John, Wigg, Alan, McCaughan, Geoff, Roberts, Stuart K., Caraceni, Paolo, Ahlenstiel, Golo, and Majumdar, Avik (2024) Efficacy of albumin use in decompensated cirrhosis and real world adoption in Australia. JGH Open, 8 (9). e70029.

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Abstract

The current treatment approach to patients with liver cirrhosis relies on the individual management of complications. Consequently, there is an unmet need for an overall therapeutic strategy for primary and secondary prevention of complications. The clinical potential of long-term albumin infusions supported by recent clinical trials has expanded its indications and holds promise to transform the management and secondary prevention of cirrhosis-related complications. This renewed interest in albumin comes with inherent controversies, compounding challenges and pressing need for rigorous evaluation of its clinical potential to capitalize on its therapeutic breakthroughs. Australia is among a few countries worldwide to adopt outpatient human albumin infusion. Here, we summarize currently available evidence of the potential benefits ofhuman albumin for the management of multiple liver cirrhosis-related complicationsand discuss key challenges for wide application of long-term albumin administration strategy in Australian clinical practice. Australian Gastroenterological week (AGW),organised by the Gastroenterological Society of Australia (GESA), was held between9-11 September 2022. A panel of hepatologists, advanced liver nurses and one haematologist, were invited to a roundtable meeting to discuss the use of long-term albumin infusions for liver cirrhosis. management in Australia. In this review, we summarise the proceedings of this meeting in context of the current literature

Item ID:	86123
Item Type:	Article (Research - C1)
ISSN:	2397-9070
Keywords:	albumin, challenges, cirrhosis, complications, decompensation, evidence, infusions, long-term
Copyright Information:	© 2024 The Author(s). JGH Open published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Funders:	Manuscript development was supported by the Ainsworth bequest to Western Sydney University and the Research and Education Network, WSLHD. The meeting and outputs reported were produced independently by the Gastroenterological Society of Australia with an
Research Data:	https://onlinelibrary.wiley.com/doi/10.1002/jgh3.70029
Date Deposited:	22 Jul 2025 04:02
FoR Codes:	32 BIOMEDICAL AND CLINICAL SCIENCES > 3214 Pharmacology and pharmaceutical sciences > 321402 Clinical pharmacology and therapeutics @ 30% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320209 Gastroenterology and hepatology @ 70%
SEO Codes:	20 HEALTH > 2001 Clinical health > 200102 Efficacy of medications @ 40% 20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 60%
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